Testosterone Cypionate Injections - Testosterone Therapy
Testosterone Cypionate Injections are used to Increase Low Testosterone Levels in Men with Andropause (Hypogonadism)
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About Testosterone Cypionate Injection, USP
By Prescription Only
Testosterone Cypionate Description
Testosterone Cypionate Description
Testosterone Cypionate Injection, USP for intramuscular injection contains Testosterone Cypionate, USP which is the oil-soluble 17 (beta)- cyclopentylpropionate ester of the androgenic hormone testosterone. Testosterone Cypionate, USP is a white or creamy white crystalline powder, odorless or nearly so and stable in air. It is insoluble in water, freely soluble in alcohol, chloroform, dioxane, ether, and soluble in vegetable oils.
The chemical name for Testosterone Cypionate, USP is androst-4-en-3-one,17-(3-cyclopentyl-1-oxopropoxy)-, (17β)-. Its molecular formula is C27H40O3, and the molecular weight 412.61.
Testosterone Cypionate Manufacturers
- Pfizer (Depo-Testosterone)
- West-Ward Pharmaceutical
- Hikma Pharmaceutical
- Sun Pharmaceutical
- Caraco Pharmaceautical
- Pharmacia and Upjohn Co.
- A-S Medication Solutions
- Physicians Total Care
Testosterone Cypionate Injection, USP is available in one strength, 200 mg/mL Testosterone Cypionate, USP.
Each mL of the 200 mg/mL solution contains:Testosterone Cypionate, USP 200 mg
Benzyl Benzoate, USP 0.2 mL
Cottonseed Oil, USP 560 mg
Benzyl Alcohol, USP (as preservative) 9.45 mg
Testosterone Cypionate - Clinical Pharmacology
Endogenous androgens are responsible for normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of the prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Drugs in this class also cause retention of nitrogen, sodium, potassium, and phosphorous, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein. Androgens are responsible for the growth spurt of adolescence and for eventual termination of linear growth, brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates, but may cause disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate production of red blood cells by enhancing production of erythropoietic stimulation factor. During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
Testosterone esters are less polar than free testosterone. Testosterone esters in oil injected intramuscularly are absorbed slowly from the lipid phase; thus, Testosterone Cypionate can be given at intervals of two to four weeks. Testosterone in plasma is 98 percent bound to a specific testosterone-estradiol binding globulin, and about 2 percent is free. Generally, the amount of this sex-hormone binding globulin in the plasma will determine the distribution of testosterone between free and bound forms, and the free testosterone concentration will determine its half-life. About 90 percent of a dose of testosterone is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites; about 6 percent of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Testosterone is metabolized to various 17-keto steroids through two different pathways. The half-life of Testosterone Cypionate when injected intramuscularly is approximately eight days.In many tissues the activity of testosterone appears to depend on reduction to dihydrotestosterone, which binds to cytosol receptor proteins. The steroid-receptor complex is transported to the nucleus where it initiates transcription events and cellular changes related to androgen action.
Indications and Usage for Testosterone Cypionate
Testosterone Cypionate Injection, USP is indicated for replacement therapy in the male in conditions associated with symptoms of deficiency or absence of endogenous testosterone.
- Primary hypogonadism (congenital or acquired)-testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome; or orchidectomy.
- Hypogonadotropic hypogonadism (congenital or acquired)-idiopathic gonadotropin or LHRH deficiency, or pituitary-hypothalamic injury from tumors, trauma, or radiation.
- Known hypersensitivity to the drug
- Males with carcinoma of the breast
- Males with known or suspected carcinoma of the prostate gland
- Women who are or who may become pregnant
- Patients with serious cardiac, hepatic or renal disease
Testosterone Cypionate Warnings
Hypercalcemia may occur in immobilized patients. If this occurs, the drug should be discontinued. Prolonged use of high doses of androgens (principally the 17-α alkyl-androgens) has been associated with development of hepatic adenomas, hepatocellular carcinoma, and peliosis hepatis —all potentially life-threatening complications. Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking. Edema, with or without congestive heart failure, may be a serious complication in patients with pre-existing cardiac, renal or hepatic disease. Gynecomastia may develop and occasionally persists in patients being treated for hypogonadism.
Androgen therapy should be used cautiously in healthy males with delayed puberty. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every 6 months. In children, androgen treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.
Testosterone Treatment Precautions
Patients with benign prostatic hypertrophy may develop acute urethral obstruction. Priapism or excessive sexual stimulation may develop. Oligospermia may occur after prolonged administration or excessive dosage. If any of these effects appear, the androgen should be stopped and if restarted, a lower dosage should be utilized. Testosterone Cypionate should not be used interchangeably with testosterone propionate because of differences in duration of action. Testosterone Cypionate is not for intravenous use.
Testosterone Information for patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, ankle swelling, too frequent or persistent erections of the penis. Laboratory tests Hemoglobin and hematocrit levels (to detect polycythemia) should be checked periodically in patients receiving long-term androgen administration. Serum cholesterol may increase during androgen therapy.
Testosterone Drug interactions
Androgens may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia. Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements. Drug/Laboratory test Interferences Androgens may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. Carcinogenesis Animal data - Testosterone has been tested by subcutaneous injection and implantation in mice and rats. The implant induced cervical-uterine tumors in mice, which metastasized in some cases. There is suggestive evidence that injection of testosterone into some strains of female mice increases their susceptibility to hepatoma. Testosterone is also known to increase the number of tumors and decrease the degree of differentiation of chemically induced carcinomas of the liver in rats. Human data. There are rare reports of hepatocellular carcinoma in patients receiving long-term therapy with androgens in high doses. Withdrawal of the drugs did not lead to regression of the tumors in all cases. Geriatric patients treated with androgens may be at an increased risk of developing prostatic hypertrophy and prostatic carcinoma although conclusive evidence to support this concept is lacking.
Testosterone and Women - PregnancyTeratogenic Effects, Pregnancy Category X - Nursing mothers - Testosterone Cypionate injection is not recommended for use in nursing mothers.
Testosterone Adverse Reactions
The following adverse reactions in the male have occurred with some androgens: Endocrine and urogenital: Gynecomastia and excessive frequency and duration of penile erections. Oligospermia may occur at high dosages. Skin and appendages: Hirsutism, male pattern of baldness, seborrhea, and acne. Fluid and electrolyte disturbances: Retention of sodium, chloride, water, potassium, calcium, and inorganic phosphates. Gastrointestinal: Nausea, cholestatic jaundice, alterations in liver function tests, rarely hepatocellular neoplasms and peliosis hepatis (see WARNINGS). Hematologic: Suppression of clotting factors II, V, VII, and X, bleeding in patients on concomitant anticoagulant therapy, and polycythemia. Nervous system: Increased or decreased libido, headache, anxiety, depression, and generalized paresthesia. Allergic: Hypersensitivity, including skin manifestations and anaphylactoid reactions. Miscellaneous: Inflammation and pain at the site of intramuscular injection.
Testosterone is a controlled substance under the Anabolic Steroids Control Act, and Testosterone Cypionate injection has been assigned to Schedule III.
Testosterone Cypionate Dosage and Administration
Testosterone Cypionate injection is for intramuscular use only. It should not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle. The suggested dosage for Testosterone Cypionate injection varies depending on the age, sex, and diagnosis of the individual patient. Dosage is adjusted according to the patient's response and the appearance of adverse reactions. Various dosage regimens have been used to induce pubertal changes in hypogonadal males; some experts have advocated lower dosages initially, gradually increasing the dose as puberty progresses, with or without a decrease to maintenance levels. Other experts emphasize that higher dosages are needed to induce pubertal changes and lower dosages can be used for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose.
For replacement in the hypogonadal male, 50 to 400 mg should be administered every two to four weeks.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Warming and shaking the vial should redissolve any crystals that may have formed during storage at temperatures lower than recommended.
Testosterone Overdosage - There have been no reports of acute overdosage with the androgens.
How is Testosterone Cypionate Supplied
Testosterone Cypionate Injection, USP, 200 mg/mL is a clear, pale yellow oleaginous viscous, sterile solution intended for intramuscular administration available as:
- 10 mL Multiple Dose Vials, Cartons of 1 vial NDC 0143-9726-01 Store at 20º to 25ºC (68º to 77ºF) [see USP Controlled Room Temperature]. Protect from light.
- Testosterone Cypionate Injection, USP CIII 2,000 mg/10 mL (200 mg/mL) NDC 0143-9726-01
- Testosterone Cypionate Injection, USP CIII 2,000 mg/10 mL One 10 mL Multiple Dose Vial NDC 0143-9726-01
Low Testosterone is a common hormonal condition in aging men. Low levels of testosterone affect a man’s professional and romantic relationships, sex drive, muscles, weight, bones, attitude and mood.
Testosterone Injections are the most effective Testosterone Therapy because they have numerous advantages over testosterone creams, testosterone gels and testosterone dermal patches. One of the biggest advantages is that the testosterone hormone is delivered directly into the bloodstream where it goes to work immediately. Most men report a difference almost right away when starting a testosterone replacement program using testosterone injections.
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At the Testosterone Rejuvenation Clinic you can get Testosterone Replacement Therapy. We offer the highest quality testosterone injections including cypionate, enanthate and propionate from top hormone producers Pfizer (Depo-Testosterone), Sandoz, Watson and Paddock. These Low T hormone medications are safe and highly effective, and most importantly produce immediate results. Testosterone injections are intramuscular injections as opposed to subcutaneous like HGH injections. When taking Testosterone shots, the hormone is injected directly into your blood stream where the drug starts to take full effect.Testosterone shots or injections can help elevate your Testosterone levels almost immediately making testosterone injections the most preferred method of testosterone replacement among men who need to significantly increase their low testosterone levels.
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The Testosterone Rejuvenation Center offers Testosterone Replacement Therapy for men and women suffering from Low T Symptoms due to Andropause or Menopause. Our Hormone Doctors have over 20 years of experience prescribing Testosterone Treatments and have been trained by the Mayo Clinic® and Cleveland Clinics®. With over 25,000 patients we can provide the best testosterone pricing. For a Free Testosterone Consultation and find out about the cost of Testosterone Therapy including Injections and Creams, fill out the Low T Therapy Info Form. Visit the Testosterone Injections page to learn about the different types of testosterone treatments available on the market - Testosterone Injections.
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Yes, you can get Testosterone Injections online, we at Optimal Testosterone Rejuvenation Centers can help you and there are many places on the Internet providing Testosterone, HCG and HGH, Human Growth Hormone for sale. However, please keep in mind it is best to buy Testosterone injections by going through the proper steps and obtaining a prescription from a licensed medical professional.
You should only buy real, high quality testosterone in injectable form from a reputable hormone therapy clinic or licensed medical practice with Testosterone Replacement experience.
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Our Testosterone Replacement Centers are managed by Board Certified medical doctors who are Mayo Clinic® and Cleveland Clinic® trained in bio-identical hormone replacement therapy. The Testosterone Injections we prescribe are only manufactured by the best FDA-Approved manufacturers. Pfizer, Paddock, Watson and Sandoz are the major producers of high quality injectable Testosterone medication products.
Testosterone is legal if you go through a licensed medical doctors and get a testosterone prescription. You will visit a medical doctor who specializes in hormone replacement for men, you will get a physical exam and have your blood drawn to ascertain your current testosterone hormone levels. You will also fill out a complete medical history form to document your symptoms and family history of medical issues. With this information your testosterone doctor can make the determination as to the level and doses required for the testosterone therapy you will receive.
Do you need a prescription for Testosterone Injections?
Yes, you need a prescription from a licensed medical doctor to get Testosterone drugs whether in person at the doctor's office or online. If you have a medical need and get a testosterone prescription from a licensed physician for Hormone Replacement Therapy, you can have Testosterone injection medications shipped to your home or office by over night or second day delivery via Fedex or UPS.
If you have any questions about buying Testosterone, getting Testosterone Injections online, or ordering Testosterone medications with a prescription, please fill out the Quick Info Form or call the Testosterone Specialists at 1-888-663-1777.
Types of Testosterone Injection for Low T Treatment
Buying the proper type of Testosterone for your Therapy
- Buying Testosterone Cypionate - Buy Testosterone Cypionate Injections
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Purchase Testosterone Cypionate - Get Testosterone Therapy for Low T Symptoms
Buying Testosterone Cypionate If you are a man with low testosterone symptoms who has been diagnosed with andropause or hypogonadism then you may be interested in where you can buy testosterone cypionate. There are many sources to buy cypionate online from manufacturers like Pfizer, West-Ward, Hikma, Watson and Paddock. This hormone medication is a drug that requires a prescription and high quality testosterone is not available in many locations outside the United States.
Many patients buy it from local hormone doctors and online. The main thing is to realize testosterone is a powerful steroid and you should only purchase it from a reputable source with a doctor's prescription and under a doctor's supervision. In a doctor-supervised hormone replacement program, you can better insure you are getting the proper dose and highest quality of testosterone on the market. Your male hormone doctor will assist you in learning how to take your testosterone injections.
What is the cost of Testosterone Therapy? Testosterone Pricing - The prices for testosterone cypionate will vary depending on your current hormone levels, your age, size and weight but your physician will discuss your testosterone treatment options with you. Depending upon the dose and frequency of injection, the price will vary. You can purchase testosterone treatment shots for weekly, bi-weekly or even monthly injection. You and your hormone doctor will consider your optimal dosage, your length of the cycle, and the potency of the hormone shot to be injected.
Buying Testosterone Cypionate Online With your testosterone prescription, you can to get your testosterone cypionate very quickly. Contact us at the Testosterone Hormone Center for pricing and info. Before you decide to buy testosterone cypionate you should evaluate your other Low T Treatment options. Most men report having the best results from injection but you may wish to explore testosterone creams or gels like Testim® and Androgel®. There are also testosterone patches like Testosderm® and Adroderm®. Some of the creams, gel and patches don't provide the absorption or comfort men need so they prefer the injectable form of testosterone therapy.
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Testosterone injections for saleCypionate is not the only type of testosterone you can find online. There is also Testosterone Enanthate and Propionate injections. If you asked, Where can I buy Testosterone, Testosterone Rejuvenation Hormone Centers can help you buy testerone injections of every type at the best possible price. We have Testosterone for Sale specials and you can save on the cost of a male hormone treatment program when you take advantage of the special pricing.
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The cost of Testosterone Therapy. Pricing for Testosterone treatments can vary depending upon how low your current levels of testosterone are, the brand of testosterone you buy, the dose of the shot and frequency of injection. Some male hormone patients pay $150 per month and others up to $500 per month depending upon their particular testosterone replacement program.
Testosterone Therapy Side Effects Like all steroids there can be great benefits but there can also be side effects if the wrong testosterone dosage is taken or your hormone doctor's instructions for injecting low t shots are not followed. Any side effects can usually be alleviated by adjusting the testosterone dose, hormone drug type or injection frequency.
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- What causes testosterone deficiency?
- What are the symptoms of testosterone deficiency or LOW T
- What changes occur in the body due to testosterone deficiency?
- How do I find out if I have a testosterone deficiency?
- How is testosterone deficiency treated
- What is the cost of testosterone programs?
- Where do I find a good testosterone doctor or clinic?
- Where can I get testosterone treatment online?
- Who shouldn't take testosterone replacement therapy?
- What are the side effects of testosterone replacement therapy?
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Testosterone Therapy Medical Team
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Rose Zegarra, PA-C