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WHAT EXACTLY IS TESTOSTERONE? HOW DOES IT AFFECT HEALTH?

"Low Testosterone or Erectile Dysfunction affects 4 in ten men between the ages of 40 and 65, - and more than four in ten over the age of 65." Treat the Symptoms and Causes of Low Androgen Levels

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Testosterone, an Anabolic Steroid, is the Male Sex Hormone and Hormone of Sexual desire in Men & Women

When Testosterone and Growth Hormone levels are Low and Cortisol High, Sexual Dysfunction can occur require Androgen Supplementation.

Many Testosterone Treatment options exist to help men increase low sex hormone levels, boost sexual desire, performance and function.


If you think you are experiencing signs and symptoms of age related hormone decline, erectile problems or sexual health issues, contact experts at the Male Health Specialists at the Men's Medical Treatment Center - 888-663-1777 or fill out the Testosterone for Men's Health Info Form. We will provide you with Testosterone Replacement Therapy TRT and Testosterone Injections, Human Growth Hormone and HCG Therapy pricing and information.


Testosterone

What exactly is Testosterone and what its affect on health in men and women?

Testosterone is the primary male sex hormone in men. It is an androgen and an anabolic steroid.

It is seen in both men and women, playing both an anabolic, androgenic and sexual health role. While females naturally generate small quantities of testosterone almost 1/10 that of men, males are the ones that produce the most testosterone. When androgen levels are low, its impact is severely felt and it is men who mostly seek to increase their levels. Read more about increasing testosterone - How do I increase my testosterone?

It is secreted in the testes by specialized cells called Leydig Cells and in the ovaries of women with a small quantity coming from the adrenal glands. Testosterone is a steroid hormone that stimulates development of male secondary sexual characteristics, produced mainly in the testes, but also in the ovaries and adrenal cortex.

Androgens like Testosterone are steroid hormones, and are created naturally and synthetically by laboratories for use in hormone therapy. The existence of androgens in tissues which have androgen receptors boosts protein synthesis in those tissues which is the anabolic effect.

Androgenic effects comprise much of that which we consider to be human maturation, particularly in reproductive and sexual organs. For instance, androgens are responsible for the maturation of male secondary features such as development of scrotum and the penis, facial and body hair, adam's apple, deep voice, larger bones and muscles.

Muscle strength and bone development characterize the anabolic effects of testosterone in men. Anabolic steroids, technically known as anabolic-androgenic steroids, are drugs that are structurally related to the cyclic steroid rings system and have similar effects to testosterone in the body. The NIH defines Anabolic steroids as the familiar name for synthetic variants of the male sex hormone testosterone. The types of testosterone used in TRT Testosterone Replacement Therapy are bio-identical or molecularly similar to those made naturally by the body.

Androgen, also called androgenic hormone or testoid, is any natural or synthetic compound, usually a steroid hormone, that stimulates or controls the development and maintenance of male characteristics

Testosterone plays a role in both females and male sexual function, during prepubescence, infancy, puberty, adolescence, and finally, adult maturity.

Androgens play a role in several processes within the body including spermatogenesis or the production of sperm.

Without testosterone and the corresponding androgen receptors, spermatogenesis can not be carried on past the meiosis cell stage reqired to produce sperm. Without sufficient andrgoen production a man can become infertile.

What causes Low Tesosterone Production?

Understanding how testosterone is created, helps us understand the reasons for low testosterone production.

There are two clinical reasons for androgen deficieny medically recognized as Primary and Secondary hypogonadism.

Deficient testosterone, usually during Andropause causes the initial, primary hypogonadism manifested by dysfunction of the Leydig cells in the testes. The cells are not functioning correctly or fully emough to secrete the required amount of testosterone needed by the body.

A Hypothalamic pituitary causes secondary hypogonadism, with resulting androgen production irregularities. The endocrine system uses a negative feedback loop to let the pituitary gland when to start and stop testosterone production. The process is regulated by having sufficient quantties of these hormones to signal the brain and in the case of secondary hypogonadism these hormones may not be working correctly. The hypothalamus and pituitary gland has a direct affect on the gonads and maintaining proper androgen levels.

How is Natural Testosterone Made

Cholesterol is the building block of hormone production. Using the hormone pregnenolone as a precursor, testosterone is synthesized in two way:

  • Cholesterol > pregnenolone > progesterone > androstenedione > Testosterone
  • Cholesterol > pregnenolone > DHEA > androstenediol > Testosterone
After production, testosterone is secreted into the bloodstream where approximately 2% circulates freely and is bio-available or free for use by a man's body. The other 96 to 98% is bound to proteins called albumin and globulin also known as SHBG or Sex Hormone Binding Globulin. The unbound Testosterone or 2% not bound to plasma proteins is known as Free Testosterone and is the biologically active part of a man's total testosterone avaialble to attach to the receptor cells in the body. Testosterone levels are regulated by the total amount of testosterone circulating in the blood stream versus the free amount ciculatinng in the blood as determoned by the levels of SHBG plasma binding proteins. As binding proteins goes increase in the blood, levels of free testosterone decrease. Anabolic steroids, human growth hormone, insulin, and amino acids can reduce the binding proteins the blood, as well increase total testosterone resulting in higher free testosterone levels.

You will remember that cells produce in the testes testosterone Leydig cells. The typical plasma concentration of testosterone in men is usually between the number of 200 – 1000 ng. In terms of timeline vs plasma concentrations over a very long time, T levels increase dramatically during adolescence, peak in a guy’s 20?s, then start a slow decline with age.

While its most powerful and broadly accepted effect on the human male body is its affect on the growth/development of tissues that are sexual, your testosterone level can also be a great index of lean body mass (ie. muscle) Possible, using the proper stimulation. Raised testosterone levels will rise Sugar uptake into muscle tissue, red blood cell production, bone density, muscle glycogen storage, and protein synthesis related to muscular Increase.

Androgen Production - Cascade of Events and Negative Feedback Loop

The cascade of events resulting in testosterone production starts in the hypothalamus together with the release of GnRH (gonadotropin releasing hormone) which works on the pituitary to make two hormones:

  • LH (luteinizing hormone) and
  • FSH (follicle stimulating hormone).

These are the gonadotropins.

Once in the bloodstream, LH makes its approach where it applies its affect on the Leydig cells, activating some events that turns cholesterol into testosterone.

As testosterone levels increase, transportation & LH production slows. A negative feedback loop.

So that you can modulate, the body and mind are conveying continuously Significant procedures. This can be only one of innumerable feedback loops (there are many positive feedback loops as well) in your body.

With this particular negative feedback loop, the brain can always keep hormone Amounts in check – in GnRH, testosterone, LH, FSH, and this instance – under Healthy conditions, regular. When a difficulty appears everywhere on this Pipeline, be it traumatic stressor, from a tumour, or summative accumulation of Little, unnoticeable noxious strain (super common) – not only is everything downstream changed, everything interval is affected.

Because it is a loop. You will find that testosterone does not just linearly use its influence back on the hypothalamus additionally, it may work back on the pituitary (basically “jumping” a measure) if your system is looking to immediately
modulate gonadotropin release.

When this endocrine feedback system is functioning correctly, male horone levels are normal. When something bad happens down the line when we run into is noticeable health issues.

FSH, another gonadotropin, is primarily accountable for sparking (or regulating) creation of sperm in the Leydig cells in the testes.

Now we realize that testosterone production is controlled by the brain, specifically the hypothalamus and pituitary, via some of Hormones that are strong. And it is synthesized following several intermediate Measures, from cholesterol in the Leydig cells. And this procedure is all connected Collectively in a negative feedback loop.

What happens after Testosterone is created ?

When testosterone is released to your bloodstream – it’s Really entering a molecular game of ‘label,’ to place it.

A carrier protein named Sex Hormone Binding Globulin, or SHBG, is Discharged in the liver, and SHBG is ‘it.’

The purpose of SHBG will be to modulate the amount of circulating testosterone in your bloodstream. When a testosterone molecule, that is bound by it Testosterone cannot efficiently enter and use its influence.

And so the more SHBG is in the bloodstream, the testosterone molecules that are fewer Really achieve a goal that is cellular.

This is not fundamentally a bad thing, it is simply the way things work.

Another negative feedback loop designed to modulate your endocrine function.

Yet, now I am hoping you are just starting to recognize the absolute number of selflimiting processes that happen across the path in this cycle… and not one of our Testosterone has really had an impact on anything

We understand that testosterone levels and with SHBG in this function SHBG levels are correlated: the more SHBG in the body, the Lower levels of T. that is free, active Again, if something little is changing ANYTHING this pathway along, You are probably going to experience a problem, establishing itself as lowerthan- Best testosterone (and associated hormone) levels.

As an example, you could have high rates of free Testosterone, but in SHBG creation, much of that with an imbalance
free T will not achieve a goal. That stinks. We’ll discuss and to free testosterone Complete testosterone farther in a bit.

How is Testosterone Used

Testosterone supplementation raises the amount of testosterone in your body when your body does not make enough natural testosterone, also known as endogenous androgens.

What is the difference between Testosterone and Anabolic Steroids?

The difference between testosterone and anabolic-androgenic steroids (AAS) is that testosterone is produced naturally by the body whereas artificial anabolics are synthetic analogs and derivatives of testosterone. They are different in terms of both formula and function. Anabolic Androgenic Steroids are synthesized in the laboratory and used clinically to treat osteoporosis and muscle-wasting endocrine disorders. Some of the most popular synthetic anabolics are nandrolone decanoate (Deca Durabolin), oxandrolone (Anavar), fluoxymesterone (Halotestin), trenbolone acetate (Parabolan), methandrostenolone (Dianabol), and oxymetholone (Anadrol). Injectable steroids are more potent, safer and remain in the system longer than oral steroids which can harm the liver due to toxicity and should be avoided or used for a very short time if possible.

Cortisol and its Role in Lowering Testosterone

Cortisol gets plenty of play in the fitness, particularly in the blogosphere World.

What exactly is Cortisol and how does it affect Testosterone Levels?

Cortisol is a glucocorticoid, a category of steroid hormone adrenal cortex. Its release is modulated by the hypothalamus (in a similar Chain of measures as we saw with testosterone) as well as the affect of CRH (corticotropin-releasing hormone).

The hypothalamus uses CRH to indicate the anterior pituitary to release another hormone called ACTH (adrenocorticotropic hormone) which Enters the bloodstream and acts Start creation, and following release, of cortisol (which can also be understood as hydrocortisone).

The Wikipedia also has more information on Cortisol.

What exactly does Cortisol do?

Baseline rates of cortisol are expected for healthy function of the body. Chronically elevated amounts are that which we should consider. You will When you realize what it does comprehend.

Cortisol plays an important part in a process called the busting, glycogenolysis. By activating the down of muscle glycogen in the muscle and liver tissue activation of an enzyme called glycogen phosphorylase. This whole The existence of epinephrine and/or triggers process norepinephrine (E/NE), also called adrenaline and noradrenaline.

E/NE are released in response to pressure (usually related to the ‘fight or flight’ response). Cortisol is additionally this small process is associated with anxiety.

Under times of anxiety, the body must really have a mechanism of activity for Allocating resources away from important things, like the immune system, and toward more immediately significant processes such as breaking down muscle glycogen.

Evolutionarily this can be essential as it enables the person under pressure or risk that is outside to fast evade risk.

Cortisol is liable because of this.

Yet, now we are able to see why raised rates of cortisol could be a negative thing. When it comes to muscle wasting elevated cortisol will cause a catabolic process called proteolysis.

It is also understood to suppress lipolysis (breakdown of fat tissue) and fall bone formation (by reducing calcium absorption in the intestines and facilitating an exchange of potassium for sodium in the cells).

Hopefully you’ll be able to observe the tendency: it seems to behave antithetically to testosterone. Insulin resistance is also facilitated by an elevated cortisol level by falling The quantity shuttled to the top of the
Cell inhibits collagen formation later, and membrane inhibits protein synthesis as a result of reduced ability of muscle tissue to uptake amino acids.

Cortisol suppresses the immune system by means of a negative feedback effect on several cytokines (interleukin-1) which disables generation of T cell growth factor. T cells are proven to really secrete a “changing Variable” (GRMF) that modulates cortisol release, so by disabling T cell Generation, cortisol has less of a checks & balances system to reply to (to anthropomorphize it all).

When it comes to brain damage elevated cortisol levels can damage cells in the hippocampus, developing a memory-deficit effect. While it works Hand in hand with E/NE to create “flash bulb” memories (brief, exceptionally
emotionally striking memories under pressure), at chronically high amounts, it Will also seriously hamper your capability to remember info that is basic.

This is the reason you feel “brain fog” during lengthy intervals of pressure at work You and or in family life may feel absent minded and forgetful. Cortisol is damaging your hippocampal neurons, inhibiting your power to remember
Advice you have already “kept”.

Ok, since the doomsday picture was painted, let us take a look Back at the process where we might want to use some, and identify To be able to control cortisol creation, keeping creation at a affect Amount that is healthful.

My vote is for the pituitary gland. Don’t forget, the pituitary secretes ACTH into the bloodstream to indicate to the adrenal cortex to secrete cortisol.

So since people possess a, and understand a lot itself Fundamental knowledge of the system, let us have a look at the interaction Between testosterone and cortisol.

Remember that when cortisol is released in response to pressure, it activates the reallocation of resources away from other body processes. One effect of This really is truly a drop in testosterone. They work.

Under ordinary conditions this can be totally wonderful; processes such as Spermatogenesis are not high on the totem pole compared to jumping out of The solution to stop from getting smacked by way of example, by way of a speeding cab.

After the stressor that is outside is finished, its homeostasis is restored by the body, lowering cortisol levels and raising the testosterone levels back to Standard.

Yet, under the affect of elevated cortisol levels, that homeostasis isn’t restored. Testosterone is suppressed. This
manifests in all manner of the outward symptoms that people normally associate with today’s “low T” outbreak.

Testosterone supports brain health.

Growth Hormone used with Testosterone

GH (or HGH) is a peptide hormone secreted in the anterior pituitary and modulated by GHRH (Growth Hormone Releasing Hormone) and GHIH (Growth Hormone Inhibiting Hormone) – both secreted from the hypothalamus.

These two ‘neurosecretory’ hormones really get discharged to the blood Encircling the pituitary and, together with physiological equilibrium (Greatly affected by things like sleep, nourishment, exercise) they act upon the pituitary gland to start secretion of GH in a pulsatile fashion.

Hopefully right now you are seeing a trend in how this works when it comes to the HPG (Hypothalamus-Pituitary-Gonadal) axis. In addition they use quite selfexplanatory names for all these hormones, which can be fine.

Growth hormone is in charge of facilitating cellular development, Reproduction in people and its particular effects, and regeneration are anabolic in nature. While you are asleep, with most of your GH release happens. Around half of it happening between periods 3 and 4 sleep. During the In upsurges every 3 to 5 hours day it is been discovered to secrete.

Here’s a fine small sketch of the typical path of actions GH can take:

Growth Hormone Complements Testosterone in the Body

HGH works together with testosterone in the body promoting stronger muscle, quicker metabolism, improved body composition, increased energy and sex drive. There are multiple methods to manipulate your GH secretion. Even only from What we have just discovered by simply affecting the equilibrium, we can quickly see that of GHRH to GHIH we had have the ability to arouse more GH secretion.

The also greatly influences those neurosecretory hormones Your body encounters are effected by physical downstream from slumber, Nutrients, and exercise – so those are some other matters we’ll investigate.

Mainly because they are the most easy quantify and to control.

Ghrelin is just another lead. It had been uncovered to be a ligand for the development hormone secretagogue receptor in 2000, I consider… which in Layman’s terms means GH release can be stimulated by its existence.

A couple other natural GH release-stimulators are heavy slumber, L DOPA, fasting, and nicotinic acid (vitamin B3).

On the reverse side, GH inhibitors that are common are:

1. high circulating levels of GH itself or IGF1 (due to the negative feedback loop)
2. glucocorticoids (ie. cortisol)
3. DHT. Raised (or even simply normalized) amounts of GH will allow it to be a lot easier for you to build muscle (via increased ability to synthesize proteins), drop fat (via promotion of lipolysis), and bare glycogen (via decreased uptake of glucose in the liver).

So the improvement of Growth Hormone would be a good thing to have.

Male Hormone Health Resources


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IMPORTANT: NO HORMONE PRESCRIPTION WILL BE PROVIDED UNLESS A CLINICAL NEED EXISTS BASED ON REQUIRED LAB WORK, PHYSICIAN CONSULTATION, PHYSICAL EXAMINATION AND CURRENT MEDICAL HISTORY. PLEASE NOTE, AGREEING TO LAB WORK AND PHYSICAL EXAM DOES NOT GUARANTEE A FINDING OF CLINICAL NECESSITY AND A PRESCRIPTION FOR HORMONE THERAPY, HORMONE REPLACEMENT TREATMENT OR PRESCRIPTION HORMONE MEDICATIONS INCLUDING TESTOSTERONE, HCG AND HUMAN GROWTH HORMONE (HGH INJECTIONS). These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. No claim or opinion on the TestosteroneTherapy.org website is intended to be nor should it be construed to be medical advice or hormone diagnosis. Please consult with a healthcare professional before starting any therapeutic program including HRT - Hormone Replacement Therapy.

  • What causes testosterone deficiency?
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  • What changes occur in the body due to testosterone deficiency?
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